Direct Interaction between <i>N</i>-Acetylcysteine and Cytotoxic Electrophile—An Overlooked In Vitro Mechanism of Protection
In laboratory experiments, many electrophilic cytotoxic agents induce cell death accompanied by reactive oxygen species (ROS) production and/or by glutathione (GSH) depletion. Not surprisingly, millimolar concentrations of <i>N</i>-acetylcysteine (NAC), which is used as a universal ROS s...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/11/8/1485 |