Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe Can Reveal Signalling Pathways in Endothelial Cells, and a Unique Mode of Receptor Activation Involving Its N-Terminal Glycan Chains

Mechanical Activation of the β2-Adrenergic Receptor by Meningococcus: A Historical and Future Perspective Analysis of How a Bacterial Probe Can Reveal Signalling Pathways in Endothelial Cells, and a Unique Mode of Receptor Activation Involving Its N-Terminal Glycan Chains

More than 12 years have passed since the seminal observation that meningococcus, a pathogen causing epidemic meningitis in humans, occasionally associated with infectious vasculitis and septic shock, can promote the translocation of β-arrestins to the cell surface beneath bacterial colonies. The cel...

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Bibliographic Details
Main Authors: Stefano Marullo, Mark G. H. Scott, Hervé Enslen, Mathieu Coureuil
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Endocrinology
Subjects:
meningococcus
β2-adrenergic receptor
β-arrestin
N-glycans
sialic acid
mechano-transduction
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.883568/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.883568/full

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