Untranslated regions (UTRs) are a potential novel source of neoantigens for personalised immunotherapy

Untranslated regions (UTRs) are a potential novel source of neoantigens for personalised immunotherapy

BackgroundNeoantigens, mutated tumour-specific antigens, are key targets of anti-tumour immunity during checkpoint inhibitor (CPI) treatment. Their identification is fundamental to designing neoantigen-directed therapy. Non-canonical neoantigens arising from the untranslated regions (UTR) of the gen...

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Bibliographic Details
Main Authors: Christopher C. T. Sng, Ashwin Adrian Kallor, Benjamin S. Simpson, Georges Bedran, Javier Alfaro, Kevin Litchfield
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
UTR
untranslated region
neoantigen
checkpoint inhibitor
personalised vaccine
PrimeCUTR
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1347542/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1347542/full

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