Spatial reversal learning in chronically sensitized rats and in undrugged sensitized rats with dopamine D2-like receptor agonist quinpirole

Spatial reversal learning in chronically sensitized rats and in undrugged sensitized rats with dopamine D2-like receptor agonist quinpirole

Dopamine plays a role in generating flexible adaptive responses in changing environments. Chronic administration of D2-like agonist quinpirole (QNP) induces behavioral sensitization and stereotypical behaviors reminiscent of obsessive-compulsive disorder (OCD). Some of these symptoms persist even af...

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Bibliographic Details
Main Authors: Hana eHatalova, Dominika eRadostová, Adéla ePištíková, Karel eVales, Ales eStuchlik
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-04-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Dopamine
Obsessive-Compulsive Disorder
Quinpirole
Reversal Learning
OCD
cognitive flexibility
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00122/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2014.00122/full

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