Physalin F induces cell apoptosis in human renal carcinoma cells by targeting NF-kappaB and generating reactive oxygen species.

Physalin F induces cell apoptosis in human renal carcinoma cells by targeting NF-kappaB and generating reactive oxygen species.

BACKGROUND: The aim of this study was to determine the molecular mechanisms of physalin F, an effective purified extract of Physalis angulata L. (Solanacae), in renal carcinoma A498 cells. METHODOLOGY/PRINCIPAL FINDINGS: Physalin F was observed to significantly induce cytotoxicity of three human ren...

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Bibliographic Details
Main Authors: Szu-Ying Wu, Yann-Lii Leu, Ya-Ling Chang, Tian-Shung Wu, Ping-Chung Kuo, Yu-Ren Liao, Che-Ming Teng, Shiow-Lin Pan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3398016?pdf=render

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http://europepmc.org/articles/PMC3398016?pdf=render

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