Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions

Age-dependent genes in adipose stem and precursor cells affect regulation of fat cell differentiation and link aging to obesity via cellular and genetic interactions

Abstract Background Age and obesity are dominant risk factors for several common cardiometabolic disorders, and both are known to impair adipose tissue function. However, the underlying cellular and genetic factors linking aging and obesity on adipose tissue function have remained elusive. Adipose s...

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Bibliographic Details
Main Authors: Asha Kar, Marcus Alvarez, Kristina M. Garske, Huiling Huang, Seung Hyuk T. Lee, Milena Deal, Sankha Subhra Das, Amogha Koka, Zoeb Jamal, Karen L. Mohlke, Markku Laakso, Sini Heinonen, Kirsi H. Pietiläinen, Päivi Pajukanta
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Medicine
Subjects:
Aging
Obesity
Polygenic risk score (PRS)
Adipose stem and precursor cells (ASPCs)
Gene-age interactions
Online Access:https://doi.org/10.1186/s13073-024-01291-x

Internet

https://doi.org/10.1186/s13073-024-01291-x

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