Pursuing High-Resolution Structures of Nicotinic Acetylcholine Receptors: Lessons Learned from Five Decades

Pursuing High-Resolution Structures of Nicotinic Acetylcholine Receptors: Lessons Learned from Five Decades

Since their discovery, nicotinic acetylcholine receptors (nAChRs) have been extensively studied to understand their function, as well as the consequence of alterations leading to disease states. Importantly, these receptors represent pharmacological targets to treat a number of neurological and neur...

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Bibliographic Details
Main Authors: Manuel Delgado-Vélez, Orestes Quesada, Juan C. Villalobos-Santos, Rafael Maldonado-Hernández, Guillermo Asmar-Rovira, Raymond C. Stevens, José Antonio Lasalde-Dominicci
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Molecules
Subjects:
nicotinic acetylcholine receptors
ligand-gated ion channel
<i>Torpedo californica</i>
<i>Torpedo marmorata</i>
cryogenic electron microscopy
crystal structure
Online Access:https://www.mdpi.com/1420-3049/26/19/5753

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https://www.mdpi.com/1420-3049/26/19/5753

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