Expression of minor cartilage collagens and small leucine rich proteoglycans may be relatively reduced in osteoarthritic cartilage

Expression of minor cartilage collagens and small leucine rich proteoglycans may be relatively reduced in osteoarthritic cartilage

Abstract Background In osteoarthritis (OA), cartilage matrix is lost despite vigorous chondrocyte anabolism. In this study, we attempted to determine whether altered matrix synthesis is involved in this paradox in disease progression through gene expression analysis and ultrastructural analysis of c...

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Bibliographic Details
Main Authors: Nobuho Tanaka, Toshiyuki Tashiro, Yozo Katsuragawa, Motoji Sawabe, Hiroshi Furukawa, Naoshi Fukui
Format: Article
Language:English
Published: BMC 2019-05-01
Series:BMC Musculoskeletal Disorders
Subjects:
Osteoarthritis
Articular cartilage
Collagen
Small leucine rich proteoglycan
Collagen fibril formation
Transmission electron mocroscopy
Online Access:http://link.springer.com/article/10.1186/s12891-019-2596-y

Internet

http://link.springer.com/article/10.1186/s12891-019-2596-y

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