The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity

The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity

Abstract Discovery of new small molecules that can activate distinct programmed cell death pathway is of significant interest as a research tool and for the development of novel therapeutics for pathological conditions such as cancer and infectious diseases. The small molecule raptinal was discovere...

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Bibliographic Details
Main Authors: Jascinta P. Santavanond, Yu-Hsin Chiu, Rochelle Tixeira, Zonghan Liu, Jeremy K. Y. Yap, Kaiwen W. Chen, Chen-Lu Li, Yi-Ru Lu, Joan Roncero-Carol, Esteban Hoijman, Stephanie F. Rutter, Bo Shi, Gemma F. Ryan, Amy L. Hodge, Sarah Caruso, Amy A. Baxter, Dilara C. Ozkocak, Chad Johnson, Zoe I. Day, Alyce J. Mayfosh, Mark D. Hulett, Thanh K. Phan, Georgia K. Atkin-Smith, Ivan K. H. Poon
Format: Article
Language:English
Published: Nature Publishing Group 2024-02-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-06513-z

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https://doi.org/10.1038/s41419-024-06513-z

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