CNS-wide repopulation by hematopoietic-derived microglia-like cells corrects progranulin deficiency in mice

CNS-wide repopulation by hematopoietic-derived microglia-like cells corrects progranulin deficiency in mice

Abstract Hematopoietic stem cell transplantation can deliver therapeutic proteins to the central nervous system (CNS) through transplant-derived microglia-like cells. However, current conditioning approaches result in low and slow engraftment of transplanted cells in the CNS. Here we optimized a bra...

Full description

Bibliographic Details
Main Authors: Pasqualina Colella, Ruhi Sayana, Maria Valentina Suarez-Nieto, Jolanda Sarno, Kwamina Nyame, Jian Xiong, Luisa Natalia Pimentel Vera, Jessica Arozqueta Basurto, Marco Corbo, Anay Limaye, Kara L. Davis, Monther Abu-Remaileh, Natalia Gomez-Ospina
Format: Article
Language:English
Published: Nature Portfolio 2024-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-49908-4

Internet

https://doi.org/10.1038/s41467-024-49908-4

Similar Items