The Mirasol Evaluation of Reduction in Infections Trial (MERIT): study protocol for a randomized controlled clinical trial

The Mirasol Evaluation of Reduction in Infections Trial (MERIT): study protocol for a randomized controlled clinical trial

Abstract Background Transfusion-transmitted infections (TTIs) are a global health challenge. One new approach to reduce TTIs is the use of pathogen reduction technology (PRT). In vitro, Mirasol PRT reduces the infectious load in whole blood (WB) by at least 99%. However, there are limited in vivo da...

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Main Authors: Ronnie Kasirye, Heather A. Hume, Evan M. Bloch, Irene Lubega, Dorothy Kyeyune, Ruchee Shrestha, Henry Ddungu, Hellen Wambongo Musana, Aggrey Dhabangi, Joseph Ouma, Priscilla Eroju, Telsa de Lange, Michael Tartakovsky, Jodie L. White, Ceasar Kakura, Mary Glenn Fowler, Philippa Musoke, Monica Nolan, M. Kate Grabowski, Lawrence H. Moulton, Susan L. Stramer, Denise Whitby, Peter A. Zimmerman, Deo Wabwire, Isaac Kajja, Jeffrey McCullough, Raymond Goodrich, Thomas C. Quinn, Robert Cortes, Paul M. Ness, Aaron A. R. Tobian
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Trials
Subjects:
Mirasol
Pathogen reduction
Transfusion-transmitted infections
Randomized controlled trial
Uganda
Sub-Saharan Africa
Online Access:https://doi.org/10.1186/s13063-022-06137-8

Internet

https://doi.org/10.1186/s13063-022-06137-8

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