A targeted metabolomics method for extra- and intracellular metabolite quantification covering the complete monolignol and lignan synthesis pathway

A targeted metabolomics method for extra- and intracellular metabolite quantification covering the complete monolignol and lignan synthesis pathway

Microbial synthesis of monolignols and lignans from simple substrates is a promising alternative to plant extraction. Bottlenecks and byproduct formation during heterologous production require targeted metabolomics tools for pathway optimization.In contrast to available fractional methods, we establ...

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Bibliographic Details
Main Authors: Andrea Steinmann, Katrin Schullehner, Anna Kohl, Christina Dickmeis, Maurice Finger, Georg Hubmann, Guido Jach, Ulrich Commandeur, Marco Girhard, Vlada B. Urlacher, Stephan Lütz
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Metabolic Engineering Communications
Subjects:
Lignans
Targeted metabolomics
Metabolite extraction
Metabolic engineering
Heterologous production
Method development
Online Access:http://www.sciencedirect.com/science/article/pii/S2214030122000141

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http://www.sciencedirect.com/science/article/pii/S2214030122000141

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