The TIP60-ATM axis regulates replication fork stability in BRCA-deficient cells
Abstract Maintenance of replication fork stability is essential for genome preservation. Stalled replication forks can be reversed by translocases such as SMARCAL1, and unless protected through the activity of the BRCA pathway, are subsequently subjected to nucleolytic degradation. The ATM and ATR k...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2022-06-01
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| Series: | Oncogenesis |
| Online Access: | https://doi.org/10.1038/s41389-022-00410-w |