The Agonist Action of Alkylphenols on TRPA1 Relates to Their Effects on Membrane Lipid Order: Implications for TRPA1-Mediated Chemosensation

The Agonist Action of Alkylphenols on TRPA1 Relates to Their Effects on Membrane Lipid Order: Implications for TRPA1-Mediated Chemosensation

The Transient Receptor Potential Ankyrin 1 cation channel (TRPA1) is a broadly-tuned chemosensor expressed in nociceptive neurons. Multiple TRPA1 agonists are chemically unrelated non-electrophilic compounds, for which the mechanisms of channel activation remain unknown. Here, we assess the hypothes...

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Bibliographic Details
Main Authors: Justyna B. Startek, Alina Milici, Robbe Naert, Andrei Segal, Yeranddy A. Alpizar, Thomas Voets, Karel Talavera
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
TRPA1
alkylphenols
mechanosensation
membrane fluidity
Laurdan
DPH
Online Access:https://www.mdpi.com/1422-0067/22/7/3368

Internet

https://www.mdpi.com/1422-0067/22/7/3368

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