Confirmation of high-throughput screening data and novel mechanistic insights into FXR-xenobiotic interactions by orthogonal assays

Confirmation of high-throughput screening data and novel mechanistic insights into FXR-xenobiotic interactions by orthogonal assays

Toxicology in the 21st Century (Tox21) is a federal collaboration employing a high-throughput robotic screening system to test 10,000 environmental chemicals. One of the primary goals of the program is prioritizing toxicity evaluations through in vitro high-throughput screening (HTS) assays for larg...

Full description

Bibliographic Details
Main Authors: Jon Hamm, Debabrata Mahapatra, Megan M. Knuth, Jaleh Abedini, Mary Lingerfelt, Sean Ekins, Seth W. Kullman
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Toxicology
Subjects:
ToxCast
Farnesoid X receptor
High-throughput screening
Teleost models
Medaka
Online Access:http://www.sciencedirect.com/science/article/pii/S2666027X22000299

Internet

http://www.sciencedirect.com/science/article/pii/S2666027X22000299

Similar Items