Bio-physiological susceptibility of the brain, heart, and lungs to systemic ischemia reperfusion and hyperoxia-induced injury in post-cardiac arrest rats

Abstract Cardiac arrest (CA) patients suffer from systemic ischemia–reperfusion (IR) injury leading to multiple organ failure; however, few studies have focused on tissue-specific pathophysiological responses to IR-induced oxidative stress. Herein, we investigated biological and physiological parame...

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Bibliographic Details
Main Authors: Tomoaki Aoki, Vanessa Wong, Yusuke Endo, Kei Hayashida, Ryosuke Takegawa, Yu Okuma, Muhammad Shoaib, Santiago J. Miyara, Tai Yin, Lance B. Becker, Koichiro Shinozaki
Format: Article
Language:English
Published: Nature Portfolio 2023-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-30120-1