Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice

Inhibition of the IRE-1α/XBP-1 pathway prevents chronic GVHD and preserves the GVL effect in mice

Abstract: Hematopoietic stem cell transplantation (HCT) is a curative procedure for hematological malignancies, but chronic graft-versus-host disease (cGVHD) remains a major complication after allogeneic HCT. Because donor B cells are essential for cGVHD development and B cells are sensitive to endo...

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Bibliographic Details
Main Authors: Steven D. Schutt, Yongxia Wu, Chih-Hang Anthony Tang, David Bastian, Hung Nguyen, M. Hanief Sofi, MengMeng Zhang, Chen Liu, Kris Helke, Carole Wilson, Lynn M. Schnapp, Juan R. Del Valle, Chih-Chi Andrew Hu, Xue-Zhong Yu
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952920310922

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http://www.sciencedirect.com/science/article/pii/S2473952920310922

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