Post-Translational Modifications of STING: A Potential Therapeutic Target
Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing essential roles in immune responses against microbial infections. However, over-activation of STING is accompanied by excessive inflammation and results in various diseases, including autoinflammatory diseas...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.888147/full |
| _version_ | 1828282022467993600 |
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| author | Jiaqi Kang Jie Wu Qinjie Liu Xiuwen Wu Yun Zhao Jianan Ren |
| author_facet | Jiaqi Kang Jie Wu Qinjie Liu Xiuwen Wu Yun Zhao Jianan Ren |
| author_sort | Jiaqi Kang |
| collection | DOAJ |
| description | Stimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing essential roles in immune responses against microbial infections. However, over-activation of STING is accompanied by excessive inflammation and results in various diseases, including autoinflammatory diseases and cancers. Therefore, precise regulation of STING activities is critical for adequate immune protection while limiting abnormal tissue damage. Numerous mechanisms regulate STING to maintain homeostasis, including protein-protein interaction and molecular modification. Among these, post-translational modifications (PTMs) are key to accurately orchestrating the activation and degradation of STING by temporarily changing the structure of STING. In this review, we focus on the emerging roles of PTMs that regulate activation and inhibition of STING, and provide insights into the roles of the PTMs of STING in disease pathogenesis and as potential targeted therapy. |
| first_indexed | 2024-04-13T08:23:34Z |
| format | Article |
| id | doaj.art-62b5aa124e1d4a09bdb3aaef35bab752 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T08:23:34Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-62b5aa124e1d4a09bdb3aaef35bab7522022-12-22T02:54:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-05-011310.3389/fimmu.2022.888147888147Post-Translational Modifications of STING: A Potential Therapeutic TargetJiaqi Kang0Jie Wu1Qinjie Liu2Xiuwen Wu3Yun Zhao4Jianan Ren5Research Institute of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of General Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, ChinaResearch Institute of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaResearch Institute of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaDepartment of General Surgery, BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Nanjing, ChinaResearch Institute of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, ChinaStimulator of interferon genes (STING) is an endoplasmic-reticulum resident protein, playing essential roles in immune responses against microbial infections. However, over-activation of STING is accompanied by excessive inflammation and results in various diseases, including autoinflammatory diseases and cancers. Therefore, precise regulation of STING activities is critical for adequate immune protection while limiting abnormal tissue damage. Numerous mechanisms regulate STING to maintain homeostasis, including protein-protein interaction and molecular modification. Among these, post-translational modifications (PTMs) are key to accurately orchestrating the activation and degradation of STING by temporarily changing the structure of STING. In this review, we focus on the emerging roles of PTMs that regulate activation and inhibition of STING, and provide insights into the roles of the PTMs of STING in disease pathogenesis and as potential targeted therapy.https://www.frontiersin.org/articles/10.3389/fimmu.2022.888147/fullSTINGpost translational modificationtargeted therapydiseasesphosphorylation |
| spellingShingle | Jiaqi Kang Jie Wu Qinjie Liu Xiuwen Wu Yun Zhao Jianan Ren Post-Translational Modifications of STING: A Potential Therapeutic Target Frontiers in Immunology STING post translational modification targeted therapy diseases phosphorylation |
| title | Post-Translational Modifications of STING: A Potential Therapeutic Target |
| title_full | Post-Translational Modifications of STING: A Potential Therapeutic Target |
| title_fullStr | Post-Translational Modifications of STING: A Potential Therapeutic Target |
| title_full_unstemmed | Post-Translational Modifications of STING: A Potential Therapeutic Target |
| title_short | Post-Translational Modifications of STING: A Potential Therapeutic Target |
| title_sort | post translational modifications of sting a potential therapeutic target |
| topic | STING post translational modification targeted therapy diseases phosphorylation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.888147/full |
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