Hyperpolarized <sup>13</sup>C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma—A Proof of Principle Study

Hyperpolarized <sup>13</sup>C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma—A Proof of Principle Study

Differentiating aggressive clear cell renal cell carcinoma (ccRCC) from indolent lesions is challenging using conventional imaging. This work prospectively compared the metabolic imaging phenotype of renal tumors using carbon-13 MRI following injection of hyperpolarized [1-<sup>13</sup>C...

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Main Authors: Stephan Ursprung, Ramona Woitek, Mary A. McLean, Andrew N. Priest, Mireia Crispin-Ortuzar, Cara R. Brodie, Andrew B. Gill, Marcel Gehrung, Lucian Beer, Antony C. P. Riddick, Johanna Field-Rayner, James T. Grist, Surrin S. Deen, Frank Riemer, Joshua D. Kaggie, Fulvio Zaccagna, Joao A. G. Duarte, Matthew J. Locke, Amy Frary, Tevita F. Aho, James N. Armitage, Ruth Casey, Iosif A. Mendichovszky, Sarah J. Welsh, Tristan Barrett, Martin J. Graves, Tim Eisen, Thomas J. Mitchell, Anne Y. Warren, Kevin M. Brindle, Evis Sala, Grant D. Stewart, Ferdia A. Gallagher
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cancers
Subjects:
cancer metabolism
hyperpolarized <sup>13</sup>C magnetic resonance imaging
monocarboxylate transporter
renal cell carcinoma
Online Access:https://www.mdpi.com/2072-6694/14/2/335

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https://www.mdpi.com/2072-6694/14/2/335

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