Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry

Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry

Background: Monoclonal antibodies (mAbs) against cancer biomarkers are key reagents in diagnosis and therapy. One such relevant biomarker is a preferentially expressed antigen in melanoma (PRAME) that is selectively expressed in many tumors. Knowing mAb’s epitope is of utmost importance for understa...

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Bibliographic Details
Main Authors: Jwala Priyadarsini Sivaccumar, Antonio Leonardi, Emanuela Iaccarino, Giusy Corvino, Luca Sanguigno, Angela Chambery, Rosita Russo, Mariangela Valletta, Debora Latino, Domenica Capasso, Nunzianna Doti, Menotti Ruvo, Annamaria Sandomenico
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
PRAME
mAb
bio-layer interferometry
epitope identification
Online Access:https://www.mdpi.com/1422-0067/22/6/3166

Internet

https://www.mdpi.com/1422-0067/22/6/3166

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