Tuning the Biological Activity of PI3K<i>δ</i> Inhibitor by the Introduction of a Fluorine Atom Using the Computational Workflow

Tuning the Biological Activity of PI3K<i>δ</i> Inhibitor by the Introduction of a Fluorine Atom Using the Computational Workflow

As a member of the class I PI3K family, phosphoinositide 3-kinase <i>δ</i> (PI3K<i>δ</i>) is an important signaling biomolecule that controls immune cell differentiation, proliferation, migration, and survival. It also represents a potential and promising therapeutic approach...

Full description

Bibliographic Details
Main Authors: Wojciech Pietruś, Mariola Stypik, Marcin Zagozda, Martyna Banach, Lidia Gurba-Bryśkiewicz, Wioleta Maruszak, Arkadiusz Leniak, Rafał Kurczab, Zbigniew Ochal, Krzysztof Dubiel, Maciej Wieczorek
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
PI3K<i>δ</i>
asthma
CPL302415
induced-fit docking
QPLD
MD
Online Access:https://www.mdpi.com/1420-3049/28/8/3531

Internet

https://www.mdpi.com/1420-3049/28/8/3531

Similar Items