Long term physicochemical stability study of novel ophthalmic formulations combining ceftazidime and vancomycin with and without cyclodextrins

Ceftazidime (CZ) and Vancomycin (VM) are used to treat bacterial keratitis; however, their physicochemical incompatibility does not allow their co-administration. This incompatibility can be managed by buffering the mixture at an alkaline pH or by using cage molecules such as cyclodextrins (CD). The...

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Bibliographic Details
Main Authors: Plaidy Pauline, Bouattour Yassine, Yessaad Mouloud, Sautou Valérie, Chennell Philip
Format: Article
Language:English
Published: De Gruyter 2023-09-01
Series:Pharmaceutical Technology in Hospital Pharmacy
Subjects:
Online Access:https://doi.org/10.1515/pthp-2023-0007