Long term physicochemical stability study of novel ophthalmic formulations combining ceftazidime and vancomycin with and without cyclodextrins
Ceftazidime (CZ) and Vancomycin (VM) are used to treat bacterial keratitis; however, their physicochemical incompatibility does not allow their co-administration. This incompatibility can be managed by buffering the mixture at an alkaline pH or by using cage molecules such as cyclodextrins (CD). The...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2023-09-01
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| Series: | Pharmaceutical Technology in Hospital Pharmacy |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pthp-2023-0007 |
| _version_ | 1827820938637344768 |
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| author | Plaidy Pauline Bouattour Yassine Yessaad Mouloud Sautou Valérie Chennell Philip |
| author_facet | Plaidy Pauline Bouattour Yassine Yessaad Mouloud Sautou Valérie Chennell Philip |
| author_sort | Plaidy Pauline |
| collection | DOAJ |
| description | Ceftazidime (CZ) and Vancomycin (VM) are used to treat bacterial keratitis; however, their physicochemical incompatibility does not allow their co-administration. This incompatibility can be managed by buffering the mixture at an alkaline pH or by using cage molecules such as cyclodextrins (CD). The objective of this work was to compare the stability during 168 days of frozen storage of two formulations combining VA and CZ at a final concentration of 25 mg/mL: a CD-free formulation, at a pH=8.5 and a formulation with CD. |
| first_indexed | 2024-03-12T01:36:11Z |
| format | Article |
| id | doaj.art-62c186938825492a98f79bdf8dcfcc13 |
| institution | Directory Open Access Journal |
| issn | 2365-2411 2365-242X |
| language | English |
| last_indexed | 2024-03-12T01:36:11Z |
| publishDate | 2023-09-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pharmaceutical Technology in Hospital Pharmacy |
| spelling | doaj.art-62c186938825492a98f79bdf8dcfcc132023-09-11T07:00:30ZengDe GruyterPharmaceutical Technology in Hospital Pharmacy2365-24112365-242X2023-09-01813516310.1515/pthp-2023-0007Long term physicochemical stability study of novel ophthalmic formulations combining ceftazidime and vancomycin with and without cyclodextrinsPlaidy Pauline0Bouattour Yassine1Yessaad Mouloud2Sautou Valérie3Chennell Philip4CHU Clermont-Ferrand, Pôle Pharmacie, Clermont-Ferrand, FranceUniversité Clermont Auvergne, CHU Clermont Ferrand, Clermont Auvergne INP, CNRS, ICCF, Clermont-Ferrand, FranceCHU Clermont-Ferrand, Pôle Pharmacie, Clermont-Ferrand, FranceUniversité Clermont Auvergne, CHU Clermont Ferrand, Clermont Auvergne INP, CNRS, ICCF, Clermont-Ferrand, FranceCHU Clermont-Ferrand, Pôle Pharmacie, Clermont-Ferrand, FranceCeftazidime (CZ) and Vancomycin (VM) are used to treat bacterial keratitis; however, their physicochemical incompatibility does not allow their co-administration. This incompatibility can be managed by buffering the mixture at an alkaline pH or by using cage molecules such as cyclodextrins (CD). The objective of this work was to compare the stability during 168 days of frozen storage of two formulations combining VA and CZ at a final concentration of 25 mg/mL: a CD-free formulation, at a pH=8.5 and a formulation with CD.https://doi.org/10.1515/pthp-2023-0007cyclodextrinsvancomycinceftazidimeophthalmic solutionphysicochemical stabilitybacterial keratitis |
| spellingShingle | Plaidy Pauline Bouattour Yassine Yessaad Mouloud Sautou Valérie Chennell Philip Long term physicochemical stability study of novel ophthalmic formulations combining ceftazidime and vancomycin with and without cyclodextrins Pharmaceutical Technology in Hospital Pharmacy cyclodextrins vancomycin ceftazidime ophthalmic solution physicochemical stability bacterial keratitis |
| title | Long term physicochemical stability study of novel ophthalmic formulations combining ceftazidime and vancomycin with and without cyclodextrins |
| title_full | Long term physicochemical stability study of novel ophthalmic formulations combining ceftazidime and vancomycin with and without cyclodextrins |
| title_fullStr | Long term physicochemical stability study of novel ophthalmic formulations combining ceftazidime and vancomycin with and without cyclodextrins |
| title_full_unstemmed | Long term physicochemical stability study of novel ophthalmic formulations combining ceftazidime and vancomycin with and without cyclodextrins |
| title_short | Long term physicochemical stability study of novel ophthalmic formulations combining ceftazidime and vancomycin with and without cyclodextrins |
| title_sort | long term physicochemical stability study of novel ophthalmic formulations combining ceftazidime and vancomycin with and without cyclodextrins |
| topic | cyclodextrins vancomycin ceftazidime ophthalmic solution physicochemical stability bacterial keratitis |
| url | https://doi.org/10.1515/pthp-2023-0007 |
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