IE1 of Human Cytomegalovirus Inhibits Necroptotic Cell Death via Direct and Indirect Modulation of the Necrosome Complex

IE1 of Human Cytomegalovirus Inhibits Necroptotic Cell Death via Direct and Indirect Modulation of the Necrosome Complex

Programmed necrosis is an integral part of intrinsic immunity, serving to combat invading pathogens and restricting viral dissemination. The orchestration of necroptosis relies on a precise interplay within the necrosome complex, which consists of RIPK1, RIPK3 and MLKL. Human cytomegalovirus (HCMV)...

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Bibliographic Details
Main Authors: Anna Theresa Heusel, Sophie Rapp, Thomas Stamminger, Myriam Scherer
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Viruses
Subjects:
necroptosis
necroptotic cell death
HCMV
cytomegalovirus
IE1
RIPK3
Online Access:https://www.mdpi.com/1999-4915/16/2/290

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https://www.mdpi.com/1999-4915/16/2/290

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