Structural insights into the enhanced carbapenemase efficiency of OXA‐655 compared to OXA‐10

Structural insights into the enhanced carbapenemase efficiency of OXA‐655 compared to OXA‐10

Carbapenemases are the main cause of carbapenem resistance in Gram‐negative bacteria. How β‐lactamases with weak carbapenemase activity, such as the OXA‐10‐type class D β‐lactamases, contribute to anti‐bacterial drug resistance is unclear. OXA‐655 is a T26M and V117L OXA‐10 variant, recently identif...

Full description

Bibliographic Details
Main Authors: Hanna‐Kirsti S. Leiros, Ane Molden Thomassen, Ørjan Samuelsen, Carl‐Fredrik Flach, Stathis D. Kotsakis, D.G. Joakim Larsson
Format: Article
Language:English
Published: Wiley 2020-09-01
Series:FEBS Open Bio
Subjects:
class D β‐lactamase
X‐ray
crystal structures
carbapenemases
antibiotic resistance
Online Access:https://doi.org/10.1002/2211-5463.12935

Internet

https://doi.org/10.1002/2211-5463.12935

Similar Items