Efficiency of multivariate tests in trials in progressive supranuclear palsy

Efficiency of multivariate tests in trials in progressive supranuclear palsy

Abstract Measuring disease progression in clinical trials for testing novel treatments for multifaceted diseases as progressive supranuclear palsy (PSP), remains challenging. In this study we assess a range of statistical approaches to compare outcomes as measured by the items of the progressive sup...

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Bibliographic Details
Main Authors: Elham Yousefi, Mohamed Gewily, Franz König, Günter Höglinger, Franziska Hopfner, Mats O. Karlsson, Robin Ristl, Sonja Zehetmayer, Martin Posch
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
Progressive supranuclear palsy
Clinical trials
Multiple endpoints
Simulation study
Item response theory
Multivariate tests
Online Access:https://doi.org/10.1038/s41598-024-76668-4

Internet

https://doi.org/10.1038/s41598-024-76668-4

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