Reversal Activity and Toxicity of Heparin-Binding Copolymer after Subcutaneous Administration of Enoxaparin in Mice

Reversal Activity and Toxicity of Heparin-Binding Copolymer after Subcutaneous Administration of Enoxaparin in Mice

Uncontrolled bleeding after enoxaparin (ENX) is rare but may be life-threatening. The only registered antidote for ENX, protamine sulfate (PS), has 60% efficacy and can cause severe adverse side effects. We developed a diblock copolymer, heparin-binding copolymer (HBC), that reverses intravenously a...

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Bibliographic Details
Main Authors: Justyna Swieton, Joanna Miklosz, Shin-Ichi Yusa, Krzysztof Szczubialka, Dariusz Pawlak, Andrzej Mogielnicki, Bartlomiej Kalaska
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
anticoagulation
antidote
block copolymer
enoxaparin
heparins
macromolecules
Online Access:https://www.mdpi.com/1422-0067/22/20/11149

Internet

https://www.mdpi.com/1422-0067/22/20/11149

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