Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation

Human DUS1L catalyzes dihydrouridine modification at tRNA positions 16/17, and DUS1L overexpression perturbs translation

Abstract Human cytoplasmic tRNAs contain dihydrouridine modifications at positions 16 and 17 (D16/D17). The enzyme responsible for D16/D17 formation and its cellular roles remain elusive. Here, we identify DUS1L as the human tRNA D16/D17 writer. DUS1L knockout in the glioblastoma cell lines LNZ308 a...

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Bibliographic Details
Main Authors: Jin Matsuura, Shinichiro Akichika, Fan-Yan Wei, Tsutomu Suzuki, Takahiro Yamamoto, Yuka Watanabe, Leoš Shivaya Valášek, Akitake Mukasa, Kazuhito Tomizawa, Takeshi Chujo
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06942-8

Internet

https://doi.org/10.1038/s42003-024-06942-8

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