Opposite Roles for ZEB1 and TMEJ in the Regulation of Breast Cancer Genome Stability

Opposite Roles for ZEB1 and TMEJ in the Regulation of Breast Cancer Genome Stability

Breast cancer cells frequently acquire mutations in faithful DNA repair genes, as exemplified by BRCA-deficiency. Moreover, overexpression of an inaccurate DNA repair pathway may also be at the origin of the genetic instability arising during the course of cancer progression. The specific gain in ex...

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Bibliographic Details
Main Authors: Mélanie K. Prodhomme, Sarah Péricart, Roxane M. Pommier, Anne-Pierre Morel, Anne-Cécile Brunac, Camille Franchet, Caroline Moyret-Lalle, Pierre Brousset, Alain Puisieux, Jean-Sébastien Hoffmann, Agnès Tissier
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
epithelial to mesenchymal transition
DNA Repair
TMEJ
DNA polymerase theta
replicative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.727429/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.727429/full

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