Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma

Hepatocyte Deletion of IGF2 Prevents DNA Damage and Tumor Formation in Hepatocellular Carcinoma

Abstract Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Serine‐arginine rich splicing factor 3 (SRSF3) plays a critical role in hepatocyte function and its loss in mice promotes chronic liver damage and leads to HCC. Hepatocyte‐specific SRSF3 knockout mice (SKO mice) also...

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Bibliographic Details
Main Authors: Deepak Kumar, Manasi Das, Alexis Oberg, Debashis Sahoo, Panyisha Wu, Consuelo Sauceda, Lily Jih, Lesley G. Ellies, Magda T. Langiewicz, Supriya Sen, Nicholas J. G. Webster
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Advanced Science
Subjects:
insulin‐like growth factor
liver cancer
prognosis
RNA splicing
Online Access:https://doi.org/10.1002/advs.202105120

Internet

https://doi.org/10.1002/advs.202105120

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