Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355

Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355

Abstract A genomic and bioactivity informed analysis of the metabolome of the extremophile Amycolatopsis sp. DEM30355 has allowed for the discovery and isolation of the polyketide antibiotic tatiomicin. Identification of the biosynthetic gene cluster was confirmed by heterologous expression in Strep...

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Bibliographic Details
Main Authors: Bernhard Kepplinger, Lina Mardiana, Joseph Cowell, Stephanie Morton-Laing, Yousef Dashti, Corinne Wills, Emma C. L. Marrs, John D. Perry, Joe Gray, Michael Goodfellow, Jeff Errington, Michael R. Probert, William Clegg, Jonathan Bogaerts, Wouter Herrebout, Nick E. E. Allenby, Michael J. Hall
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-18726-3

Internet

https://doi.org/10.1038/s41598-022-18726-3

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