PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate

PTEN Protein Phosphatase Activity Is Not Required for Tumour Suppression in the Mouse Prostate

Loss PTEN function is one of the most common events driving aggressive prostate cancers and biochemically, PTEN is a lipid phosphatase which opposes the activation of the oncogenic PI3K-AKT signalling network. However, PTEN also has additional potential mechanisms of action, including protein phosph...

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Bibliographic Details
Main Authors: Helen M. Wise, Adam Harris, Nisha Kriplani, Adam Schofield, Helen Caldwell, Mark J. Arends, Ian M. Overton, Nick R. Leslie
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
tumour suppressor
prostate cancer
PTEN
phosphatase
PI 3-Kinase
Online Access:https://www.mdpi.com/2218-273X/12/10/1511

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https://www.mdpi.com/2218-273X/12/10/1511

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