Expansion of macrophage and liver sinusoidal endothelial cell subpopulations during non-alcoholic steatohepatitis progression

Expansion of macrophage and liver sinusoidal endothelial cell subpopulations during non-alcoholic steatohepatitis progression

Summary: Liver non-parenchymal cells (NPCs) play a critical role in the progression of non-alcoholic steatohepatitis (NASH). We aimed to explore the heterogeneity of NPCs and identify NASH-specific subpopulations contributing to NASH progression. Through single-cell RNA sequencing, we uncovered a pr...

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Bibliographic Details
Main Authors: Zhenyang Shen, Bo Shen, Weiming Dai, Cui Zhou, Xin Luo, Yuecheng Guo, Junjun Wang, Xianjun Xu, Zhongshang Sun, Xiaobo Cai, Hui Dong, Lungen Lu
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Immunology
Cell biology
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223006491

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http://www.sciencedirect.com/science/article/pii/S2589004223006491

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