Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA

Luminescent platinum(II) complexes with functionalized N-heterocyclic carbene or diphosphine selectively probe mismatched and abasic DNA

DNA pairing defects such as mismatched and abasic DNA are prevalent in cancer cells. Here, the authors present luminescent platinum based probes capable of preferentially binding to mismatched and abasic DNA, and reporting this by a significant luminescence enhancement

Bibliographic Details
Main Authors: Sin Ki Fung, Taotao Zou, Bei Cao, Tianfeng Chen, Wai-Pong To, Chen Yang, Chun-Nam Lok, Chi-Ming Che
Format: Article
Language:English
Published: Nature Portfolio 2016-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10655

Internet

https://doi.org/10.1038/ncomms10655

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