A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling

A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling

Homeostatic synaptic plasticity requires widespread remodeling of synaptic signaling and scaffolding networks, but the role of post-translational modifications in this process has not been systematically studied. Using deep-scale quantitative analysis of the phosphoproteome in mouse neocortical neur...

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Bibliographic Details
Main Authors: Chi-Hong Wu, Vedakumar Tatavarty, Pierre M Jean Beltran, Andrea A Guerrero, Hasmik Keshishian, Karsten Krug, Melanie A MacMullan, Li Li, Steven A Carr, Jeffrey R Cottrell, Gina G Turrigiano
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-04-01
Series:eLife
Subjects:
synaptic scaling
homeostatic plasticity
phosphorylation
Online Access:https://elifesciences.org/articles/74277

Internet

https://elifesciences.org/articles/74277

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