p85β alters response to EGFR inhibitor in ovarian cancer through p38 MAPK-mediated regulation of DNA repair

p85β alters response to EGFR inhibitor in ovarian cancer through p38 MAPK-mediated regulation of DNA repair

EGFR signaling promotes ovarian cancer tumorigenesis, and high EGFR expression correlates with poor prognosis. However, EGFR inhibitors alone have demonstrated limited clinical benefit for ovarian cancer patients, owing partly to tumor resistance and the lack of predictive biomarkers. Cotargeting EG...

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Bibliographic Details
Main Authors: Victor CY Mak, Xinran Li, Ling Rao, Yuan Zhou, Sai-Wah Tsao, Lydia WT Cheung
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Epidermal growth factor receptor
Erlotinib
PI3K
p85 regulatory subunit
DNA repair
p38 MAPK
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558621000348

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http://www.sciencedirect.com/science/article/pii/S1476558621000348

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