A novel mitochondrial complex I ROS inhibitor partially improves muscle regeneration in adult but not old mice

A novel mitochondrial complex I ROS inhibitor partially improves muscle regeneration in adult but not old mice

It is unclear whether mitochondrial dysfunction and redox stress contribute to impaired age-related muscle regenerative capacity. Here we characterized a novel compound, BI4500, that inhibits the release of reactive oxygen species (ROS) from the quinone site in mitochondrial complex I (site IQ). We...

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Bibliographic Details
Main Authors: Gavin Pharaoh, Ethan L. Ostrom, Rudy Stuppard, Matthew Campbell, Jens Markus Borghardt, Michael Franti, Antonio Filareto, David J. Marcinek
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Redox Biology
Subjects:
Reverse electron transport (RET)
Muscle injury and regeneration
Mitochondrial reactive oxygen species (ROS)
Barium chloride injury
Sarcopenia
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723001714

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http://www.sciencedirect.com/science/article/pii/S2213231723001714

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