Direct RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen

Direct RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen

Here, Depledge et al. use nanopore arrays for direct RNA sequencing to profile the HSV-1 transcriptome in productively infected cells. Sequencing of individual RNAs reveals a highly complex viral transcriptome including mRNAs encoding new viral fusion proteins derived by read-through transcription.

Bibliographic Details
Main Authors: Daniel P. Depledge, Kalanghad Puthankalam Srinivas, Tomohiko Sadaoka, Devin Bready, Yasuko Mori, Dimitris G. Placantonakis, Ian Mohr, Angus C. Wilson
Format: Article
Language:English
Published: Nature Portfolio 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08734-9

Internet

https://doi.org/10.1038/s41467-019-08734-9

Similar Items