Single Amino Acid Deletion at N-Terminus of the Target Antigen in DNA Vaccine Induces Altered CD8<sup>+</sup> T Cell Responses against Tumor Antigen

Single Amino Acid Deletion at N-Terminus of the Target Antigen in DNA Vaccine Induces Altered CD8<sup>+</sup> T Cell Responses against Tumor Antigen

Since CD8<sup>+</sup> T cells have immunological memory and can eliminate tumor or infected cells, antigen-specific CD8<sup>+</sup> T cell inducing DNA vaccines are potential next-generation vaccines. However, the relationship between single amino acid deletion of target anti...

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Bibliographic Details
Main Author: Takashi Imai
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Vaccines
Subjects:
DNA vaccine
immunology
CD8<sup>+</sup> T cell
antigen presentation
proteasome
tumor
Online Access:https://www.mdpi.com/2076-393X/9/6/540

Internet

https://www.mdpi.com/2076-393X/9/6/540

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