Combined Genetic Association and Differed Expression Analysis of UBE2L3 Uncovers a Genetic Regulatory Role of (Immuno)proteasome in IgA Nephropathy

Combined Genetic Association and Differed Expression Analysis of UBE2L3 Uncovers a Genetic Regulatory Role of (Immuno)proteasome in IgA Nephropathy

Introduction: IgA nephropathy (IgAN) is a leading cause of end-stage renal disease. The exact pathogenesis of IgAN is not well defined, but some genetic studies have led to a novel discovery that the (immuno)proteasome probably plays an important role in IgAN. Methods: We firstly analyzed the associ...

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Bibliographic Details
Main Authors: Lin-Lin Xu, Ting Gan, Yang Li, Pei Chen, Su-Fang Shi, Li-Jun Liu, Ji-Cheng Lv, Hong Zhang, Xu-Jie Zhou
Format: Article
Language:English
Published: Karger Publishers 2024-03-01
Series:Kidney Diseases
Subjects:
iga nephropathy
immunoproteasome
ubiquitin-conjugating enzyme
ubiquitin-proteasome system
Online Access:https://beta.karger.com/Article/FullText/537987

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https://beta.karger.com/Article/FullText/537987

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