Erythropoietin mediates re-programming of endotoxin-tolerant macrophages through PI3K/AKT signaling and protects mice against secondary infection

Erythropoietin mediates re-programming of endotoxin-tolerant macrophages through PI3K/AKT signaling and protects mice against secondary infection

Initial lipopolysaccharide (LPS) exposure leads to a hypo-responsive state by macrophages to a secondary stimulation of LPS, known as endotoxin tolerance. However, recent findings show that functions of endotoxin-tolerant macrophages are not completely suppressed, whereas they undergo a functional r...

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Bibliografski detalji
Glavni autori: Xue Zhang, Dan He, Jialin Jia, Feihong Liang, Jie Mei, Wenhua Li, Tingting Liu, Zhiyu Wang, Yu Liu, Fengxue Zhang, Zhiren Zhang, Bangwei Luo
Format: Članak
Jezik:English
Izdano: Frontiers Media S.A. 2022-08-01
Serija:Frontiers in Immunology
Teme:
endotoxin tolerance
sepsis
macrophages
HIF-1α
erythropoietin
Online pristup:https://www.frontiersin.org/articles/10.3389/fimmu.2022.938944/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.938944/full

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