Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer’s disease

Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer’s disease

Extracellular amyloid beta (Aβ) plaques are main pathological feature of Alzheimer’s disease. However, the specific type of neurons that produce Aβ peptides in the initial stage of Alzheimer’s disease are unknown. In this study, we found that 5-hydroxytryptamin receptor 3A subunit (HTR3A) was highly...

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Bibliographic Details
Main Authors: Li-Fen Liu, Yu-Tong Liu, Dan-Dan Wu, Jie Cheng, Na-Na Li, Ya-Ni Zheng, Liang Huang, Qiong-Lan Yuan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Neural Regeneration Research
Subjects:
5-hydroxytryptamin receptor 3; alzheimer’s disease; amyloid beta plaques; calcineurin; cognitive deficits; htr3 interneurons; ica2+; nuclear factor of activated t-cells; transgenic amyloid precursor protein and presenilin-1 mice; tropisetron
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=2019;epage=2028;aulast=Liu

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2023;volume=18;issue=9;spage=2019;epage=2028;aulast=Liu

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