TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo

TRIM28-Mediated Excessive Oxidative Stress Induces Cellular Senescence in Granulosa Cells and Contributes to Premature Ovarian Insufficiency In Vitro and In Vivo

Premature ovarian insufficiency (POI) is a clinical syndrome of ovarian dysfunction characterized by the abnormal alteration of hormone levels such as FSH and E<sub>2</sub>. POI causes infertility, severe daily life disturbances, and long-term health risks. However, the underlying mechan...

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Bibliographic Details
Main Authors: Chong Zhou, Dandan Li, Jinxia He, Tao Luo, Yiting Liu, Yue Xue, Jian Huang, Liping Zheng, Jia Li
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Antioxidants
Subjects:
premature ovarian insufficiency
granulosa cells
cellular senescence
oxidative stress
autophagy
TRIM28
Online Access:https://www.mdpi.com/2076-3921/13/3/308

Internet

https://www.mdpi.com/2076-3921/13/3/308

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