SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells

SMYD3 associates with the NuRD (MTA1/2) complex to regulate transcription and promote proliferation and invasiveness in hepatocellular carcinoma cells

Abstract Background SMYD3, a member of the SET and MYND domain-containing (SMYD) family, is a histone methyltransferase (HMT) and transcription factor that plays an important role in transcriptional regulation in human carcinogenesis. Results Using affinity purification and mass spectrometry assays...

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Bibliographic Details
Main Authors: Yang Yang, Rongfang Qiu, Siyu Zhao, Lin Shen, Bufu Tang, Qiaoyou Weng, Ziwei Xu, Liyun Zheng, Weiqian Chen, Gaofeng Shu, Yajie Wang, Zhongwei Zhao, Minjiang Chen, Jiansong Ji
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Biology
Subjects:
SMYD3
Hepatocellular carcinoma
NuRD complex
IGFBP4
Metastasis
Online Access:https://doi.org/10.1186/s12915-022-01499-6

Internet

https://doi.org/10.1186/s12915-022-01499-6

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