Fisetin represses oxidative stress and mitochondrial dysfunction in NAFLD through suppressing GRP78-mediated endoplasmic reticulum (ER) stress

Fisetin represses oxidative stress and mitochondrial dysfunction in NAFLD through suppressing GRP78-mediated endoplasmic reticulum (ER) stress

Fisetin (FisT) is a bioactive flavonoid polyphenol with antioxidant, anti-inflammatory and anti-tumor activities. Although the effects of FisT to meliorate non-alcoholic fatty liver disease (NAFLD) have been investigated, the underlying mechanisms are not fully understood. In the present study, we f...

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Bibliographic Details
Main Authors: Xianling Dai, Qin Kuang, Yan Sun, Minxuan Xu, Liancai Zhu, Chenxu Ge, Jun Tan, Bochu Wang
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Journal of Functional Foods
Subjects:
NAFLD
Fisetin
ROS
Mitochondrial impairment
ER stress
Online Access:http://www.sciencedirect.com/science/article/pii/S175646462200024X

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http://www.sciencedirect.com/science/article/pii/S175646462200024X

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