Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias

Determining the Effects of Differential Expression of GRKs and β-arrestins on CLR-RAMP Agonist Bias

Signalling of the calcitonin-like receptor (CLR) is multifaceted, due to its interaction with receptor activity modifying proteins (RAMPs), and three endogenous peptide agonists. Previous studies have focused on the bias of G protein signalling mediated by the receptor and receptor internalisation o...

Full description

Bibliographic Details
Main Authors: Abigail Pearce, Theo Redfern-Nichols, Matthew Harris, David R. Poyner, Mark Wigglesworth, Graham Ladds
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Physiology
Subjects:
GPCRs (G protein-coupled receptors)
signalling bias
CLR
β-arrestins
RAMPs
internalisation
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.840763/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.840763/full

Similar Items