Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases

Evidence linking APOBEC3B genesis and evolution of innate immune antagonism by gamma-herpesvirus ribonucleotide reductases

Viruses have evolved diverse mechanisms to antagonize host immunity such as direct inhibition and relocalization of cellular APOBEC3B (A3B) by the ribonucleotide reductase (RNR) of Epstein-Barr virus. Here, we investigate the mechanistic conservation and evolutionary origin of this innate immune cou...

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Bibliographic Details
Main Authors: Sofia N Moraes, Jordan T Becker, Seyed Arad Moghadasi, Nadine M Shaban, Ashley A Auerbach, Adam Z Cheng, Reuben S Harris
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-12-01
Series:eLife
Subjects:
APOBEC3B
evolutionary arms race
herpesvirus
host-pathogen interaction
ribonucleotide reductase
viral evolution
Online Access:https://elifesciences.org/articles/83893

Internet

https://elifesciences.org/articles/83893

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