The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function

Abstract Background Microglia are essential to maintain cell homeostasis in the healthy brain and are activated after brain injury. Upon activation, microglia polarize towards different phenotypes. The course of microglia activation is complex and depends on signals in the surrounding milieu. Recent...

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Bibliographic Details
Main Authors: Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Monière, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Neuroinflammation
Subjects:
Neuroinflammation
Cerebral ischemia
Ion channel
Ih-current
ZD7288
XE-991
Online Access:http://link.springer.com/article/10.1186/s12974-020-01779-4

Internet

http://link.springer.com/article/10.1186/s12974-020-01779-4

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