Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety

Evaluation of a non-animal toolbox informed by adverse outcome pathways for human inhalation safety

IntroductionThis work evaluated a non-animal toolbox to be used within a next-generation risk assessment (NGRA) framework to assess chemical-induced lung effects using human upper and lower respiratory tract models, namely MucilAir™-HF and EpiAlveolar™ systems, respectively.MethodsA 12-day substance...

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Bibliographic Details
Main Authors: Renato Ivan de Ávila, Iris Müller, Hugh Barlow, Alistair Mark Middleton, Mathura Theiventhran, Danilo Basili, Anthony M. Bowden, Ouarda Saib, Patrik Engi, Tymoteusz Pietrenko, Joanne Wallace, Bernadett Boda, Samuel Constant, Holger Peter Behrsing, Vivek Patel, Maria Teresa Baltazar
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Toxicology
Subjects:
inhalation risk assessment
lung exposure modelling
lung toxicity
new approach methodologies
nonanimal testing
point of departure
Online Access:https://www.frontiersin.org/articles/10.3389/ftox.2025.1426132/full

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https://www.frontiersin.org/articles/10.3389/ftox.2025.1426132/full

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