Select HDAC Inhibitors Enhance Osteolysis and Bone Metastasis Outgrowth but Can Be Mitigated With Bisphosphonate Therapy

Select HDAC Inhibitors Enhance Osteolysis and Bone Metastasis Outgrowth but Can Be Mitigated With Bisphosphonate Therapy

ABSTRACT Breast cancer has a high predilection for spreading to bone with approximately 70% of patients who succumb to disease harboring bone disseminated tumor cells. Despite this high prevalence, treatments for bone metastatic breast cancer predominantly manage morbidities, including pain and hype...

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Bibliographic Details
Main Authors: Miranda E Clements, Lauren Holtslander, Joshua R Johnson, Rachelle W Johnson
Format: Article
Language:English
Published: Oxford University Press 2023-03-01
Series:JBMR Plus
Subjects:
BREAST CANCER
HISTONE DEACETYLASE INHIBITORS
BONE METASTASIS
Online Access:https://doi.org/10.1002/jbm4.10694

Internet

https://doi.org/10.1002/jbm4.10694

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